Z370010
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Z370010
Sigma
Antisense Therapeutics
| ISBN-10: | 0-89603-305-8 |
| ISBN-13: | 978-0-89603-305-4 |
Description
| General description | An authoritative survey of this fascinating strategy for drug discovery: using complementary oligonucleotides to block expression of disease-associated genes. Contributors discuss selection of gene targets, synthesis of oligonucleotides, routes of administration, and issues of pharmacokinetics. Current research on anti-viral drugs, cancer treatment, and therapies for genetic disorders is summarized. |
Properties
| publication info | S. Agrawal, ed., Humana Press, US, 1996, 304 pp., hard cover |
Table Of Contents
| Table of Contents | History of Antisense Oligonucleotides. Pharmacology of Antisense Therapeutic Agents: Cancer and Inflammation. Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models. Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo. Antisense Tumor Therapy: Activated C-Ha-ras Oncogene in the Mouse. Antisense Inhibition of Protein Synthesis and Function: Rabbit Retinal Protein. c-Myb in Smooth Muscle Cells. Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model. Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design, Pharmacokinetics, Intracerebral Application, and Organ Uptake of Phosphorothioate Oligodeoxynucleotides. Antisense rel A in Cancer. Continuous Infusion of Antisense Phosphorothioate Therapeutics. Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo: The Antisense Effects Outlast Antisense Survival. Antisense Therapeutics in the Central Nervous System: The Induction of c-fos. Comparative Pharmacokinetics of Antisense Oligonucleotides. Index. |
